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Pendopharm offers a strong orthopedics portfolio for the treatment of osteoarthritis of the knee.

Cingal logo
One injection for fast* pain relief
Monovisc logo
One injection for long-term pain relief
Orthovisc logo
Three injections for long-term pain relief
Fast pain relief
yes
Clinically proven long-term pain relief
yes
yes
yes
Single injection
yes
yes
Multi-injection
  • Ideal for close monitoring
yes
Non-avian
yes
yes
yes
Generally well tolerated
yes
yes
yes
Light cross-linking properties of HA for better8
  • Viscoelasticity
  • Residence time in the joint
  • Elasticity
yes
yes
Injection volume
4 mL
4 mL
2 mL
An effective HA concentration
22 mg/mL
20 mg/mL
15 mg/mL
Total HA delivered/injection
88 mg
80 mg
30 mg
More about Cingal® More about Monovisc® More about Orthovisc®

HA : hyaluronic acid; WOMAC : Western Ontario and McMaster Universities Arthritis Index; OA : osteoarthritis; VAS : visual analog scale

*Significant reduction in WOMAC score from baseline seen at Week 1 vs. saline (ITT p=0.008).

†A randomized, double-blinded, multicentre, placebo-controlled study (with an active comparator arm) to evaluate the safety and effectiveness of a single injection of Cingal® in patients with symptomatic OA of the knee. A total of 368 patients were enrolled and randomized in a 2:2:1 ratio to Cingal®, Monovisc®, or saline injection. The primary endpoint was the change from baseline in knee pain as measured by the WOMAC Pain Score (100 mm VAS) through 12 weeks post treatment comparing the Cingal® group to the saline control group.

‡Significant reduction in WOMAC score from baseline seen at Week 26 vs. saline (ITT p=0.0352).

Cingal® (hyaluronic acid and triamcinolone hexacetonide) is indicated for the treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and to simple analgesics (e.g., acetaminophen). Cingal® includes an ancillary steroid to provide additional short-term pain relief.

Monovisc® is indicated in the treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and to simple analgesics, e.g., acetaminophen.

Orthovisc® is indicated for the symptomatic treatment of osteoarthritis of the knee.